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Sabo, Ph.D., Inmaculada Aban, Ph.D., Huichien Kuo, M.S., Scott H. James, M.D., Mark N. Prichard, Ph.D., Jill Griffin, R.N., Dusty Giles, R.N., Edward P. Acosta, Pharm.D., and Richard J. Whitley, M.D. For the National Institute of Allergy and Infectious Diseases Collaborative Antiviral Research Group: Valganciclovir for Symptomatic Congenital Cytomegalovirus Disease Congenital cytomegalovirus infection may be the leading nongenetic cause of sensorineural hearing loss1-4 and is the most frequent known viral reason behind mental retardation5; the an infection affects 0.6 to 0.7 percent of live births in industrialized countries.6-8 A total of 10 percent of congenitally infected neonates have symptomatic disease at birth, of whom 35 percent have sensorineural hearing loss, up to two thirds have neurologic deficits, and 4 percent die through the newborn period.7-11 Although congenital CMV infection is rare overall, it makes up about 21 percent of children with hearing loss in birth and 24 percent of these with hearing loss in 4 years.1,12 The National Institute of Allergy and Infectious Illnesses Collaborative Antiviral Study Group discovered that among neonates with symptomatic congenital CMV disease involving the central nervous system , ganciclovir administered intravenously over an interval of 6 weeks was associated with improved audiologic outcomes at 6 months of life, but there was suggestion that benefit could wane over the first 2 years of life.13 Treated infants acquired fewer developmental delays, relating to Denver Developmental evaluations, than untreated infants.14 In a follow-up study, the CASG determined the dosage of oral valganciclovir that results in systemic contact with ganciclovir that’s similar to that with intravenous ganciclovir.15 Therapy with intravenous ganciclovir or oral valganciclovir for 6 weeks is currently a recognized treatment option for patients with symptomatic congenital CMV disease involving the CNS.16 Methods Research Design and Population Neonates with symptomatic congenital CMV disease, with or without CNS involvement, were eligible for enrollment.This experience is wanted by me. Reread Parvati, Tommy, etc. Helped.

Travel Time May Hamper Follow-Up Chemo, Research Says: – MONDAY, Aug. 24, 2015 – – The farther they need to travel, the not as likely cancer individuals are to get follow-up chemotherapy after medical procedures, a new study finds. This kind of treatment, called adjuvant chemotherapy, is recommended for many patients after surgery to reduce the chance of cancer returning. This study looked at 34 nearly,700 patients over the United States who had surgery for cancer of the colon, and discovered that nearly 76 % received adjuvant chemotherapy within 3 months of surgery.