25 AugAccording to new study results.

Gene Mutation Helps Predict Thyroid Cancer TreatmentA specific gene mutation in predicting the in predicting the aggressiveness of thyroid cancer and help guide treatment options and follow-up, according to new study results. – mutation, called BRAF V600E, is a genetic alteration in the BRAF oncogene, a modified gene believed to cause cancer. The new research is reported in the September issue of of the Annals of Surgery.

They found the mutation in 51 % of patients with conventional PTC, in 1 % of patients with follicular thyroid cancer, and in 24.1 % of patients with follicular variant PTC.In conventional PTC and follicular variant PTC, the mutation was significantly associated with older, larger tumor size, and recurrent and persistent disease. These patients also showed a trend to a higher rate of cancer in the lymph nodes by metastasis and higher stage cancer.UCSF is a leading university that advances health worldwide by conducting advanced biomedical research, training in the life sciences and health professions, and the complex patient care students..Elledge research at an alternative hypothesis, that is that STOP genes can in a and hemizygous Clear be haploinsufficient it is not recessive trait, indicating that it depends on two copies of to function normally. If a tumor Suppressors haploinsufficient, it an individual copy of the gene requires power in order completely retain tumorigenesis lacking, Elledge explains who. Also an Howard Hughes Medical Institute Investigator clusters clusters from haploinsufficient Generate at a time, the cancer cells driving his growth forwards immediately, in for the other copies of lost also. .

The elimination of the cluster there a larger of bang for the buck cancellation, he said. So is especially interesting in terms of two -hit model of cancer, which two copies of a recessive gene must be inactivated to trigger a biological effect apply. Thus, of the loss of a single tumor suppressing copy of should be with little or no influence on proliferation of tumor cells , as the remaining Print on the other chromosome lies there pick up the slack.. An research team led by Stephen Elledge, a professor in the Department of Genetics at Harvard Medical School and his postdoctoral fellow Nicole mini solo, has now provided an answer is available.